LNP Encapsulation CRO Services

Advanced LNP Encapsulation: Empowering Early-Stage Scientific Discovery

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Enorna provides research-grade LNP encapsulation services built on deep expertise in lipid design, including both commercial and novel ionizable lipids.

Utilizing our proprietary library of cationic lipid molecules, we support formulation screening to identify high-efficiency, low-toxicity, and tissue-specific delivery systems. Our platform delivers comprehensive support for preclinical in vitro and in vivo studies, accelerating the development of innovative nucleic acid therapeutics.

Why Us
1Advanced LNP Encapsulation Technology

Customizable purification strategies tailored to diverse application needs

GMP‑aligned microfluidic platform ensuring high batch‑to‑batch consistency

Flexible and comprehensive testing panels that guarantee delivery system quality

2Novel Cationic Lipid Screening Solutions

Commercial lipids (e.g. SM-102, etc.)

Enorna-recommended foumulations (clear IP ownership)

Client-supplied Lipids

3Flexible and Scalable Production

GLP-grade batches up to 300 mL; larger-scale production available through CDMO services

Seamless transition from preclinical research to clinical-stage development

LNP CDMO Solutions
Services

We provide research grade and preclinical grade LNP services for both in vitro and in vivo studies.

 
Research Grade
GLP Grade
LNP Options

1) Commercial Lipids (e.g. SM-102, etc.)

2) Enorna-Recommended Foumulations (Clear IP Ownership)

3) Client-Supplied Lipids

1) Commercial Lipids (e.g. SM-102, etc.)

2) Enorna-Recommended Foumulations (Clear IP Ownership)

3) Client-Supplied Lipids

Scale
<40 mL
100-300 mL
Turnaround Time
4 Business Days
4 Business Days
Deliverable

a) RNA-LNP Product

b) ROA

a) RNA-LNP Product

b) ROA

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Testing Panel
Item
Method
Standard
Research Grade
GLP Grade
Appearance
Visual Inspection
Clear, Free of Visible Particles
Final Concentration
RiboGreen Fluorescence Assay
0.05 – 0.4 mg/mL
Encapsulation Efficiency (EE)
RiboGreen Fluorescence Assay
> 85%
Integrity of Encapsulated RNA
Bioanalyzer

<4k nt: ≥75%

>4k nt: Reported Value

Particle Size (Diameter)
Dynamic Light Scattering (DLS)

MC3-LNP 80-110 nm

SM102-LNP 65-125 nm

LP01-LNP 65-125 nm

ALC0315-LNP 50-100 nm

Polydispersity Index (PDI)
Dynamic Light Scattering (DLS)
< 0.3
Zeta Potential
Dynamic Light Scattering (Zetasizer)
± 15.0 mV
pH
pH Meter
7.4 ± 0.5
Endotoxin
Semiquantitative Test
<10 EU/ml
Bioburden
Direct Inoculation
No Growth after 72 Hours

Y

N

Optional

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